Synthesis, design, biological and anti-oxidant assessment of some new 9H-carbazole derivatives

Abstract

This research includes the synthesis of 9H-carbazole compounds (1-7) through the prepared ester by condensation 9H-Carbazole with chloroacetic acid in the presence of triethylamine and benzene as a solvent. The compound (3) was prepared from ester and ethanol in the presence of H₂SO₄ as catalyst by using MWI. The synthesis of amide carbazole derivatives (3,4,5) was accomplished by using microwave irradiation with aromatic amine (p-, o-bromoaniline and m-chloroaniline). The synthesis of derivatives (6,7) was performed by Suzuki coupling reaction during which derivative (5) was treated with aryl boronic acid using pd(pph₃)₄ ʺpalladium-tetrakis(triphenyl phosphine)ʺ as a catalyst via oxidation, transformation and reduction steps. The synthesized compounds were evaluated by FT-IR, 1H-NMR, 13C-NMR spectra. The assay of biological/antibacterial activity of synthesized compounds against two types of bacteria i.e. gram-positive (Staphy. Aureus) and gram-negative (E. coli) were performed. The results exhibited excellent activity of all synthesized compounds as compared with ciprofloxacin drug. The antioxidant activity of the synthesized compounds using DPPH test showed good findings.